8 Best Hybrid Weed Strains of 2024 for Pain Relief, Relaxation & More (2024)

By Corey B. Harrison

From Sativa strains to Indica varieties and the intriguing selection of hybrid cannabis strains, the options are limitless, especially since we know that there are over 700 cannabis strains.

However, this article is entirely devoted to the mighty selection of popular hybrids, and for this specific occasion, we look into eight cannabis hybrids.

We start our journey by looking into the Northern Lights hybrid strain you can shop for at Seed Supreme, but the selection also includes seven other popular hybrids, each with its unique effects and distinct flavor profile.

With so much to discuss, we want to jump right into the topic, so buckle up and let’s go!

Best Hybrid Cannabis Strains – First Look

Northern Lights – Best overall (guaranteed germination)
Granddaddy Purple – Calming and relaxing effect
Gorilla Glue #4 – Relaxation mixing with euphoria
Chocolope Fem – Body and mind stimulation
Grape Ape – Ideal for experienced users
Green Gelato – Stress-relieving effects
Runtz Muffin – Very high THC content
Wedding Cake – Blend of aromatic compounds

While the Sativa-dominant cannabis strains are known for their cerebral stimulation and energizing effect, the Indica-dominant strains are famed for their soothing and relaxing effects.

Hybrid cannabis strains combine the best of both worlds, so depending on which cannabis strain you choose, you may experience a range of intense effects. We look into the eight most popular hybrids and examine their THC potency and other standout features.

1. Northern Lights – Best Hybrid Strain Overall

Pros:

THC potency between 16% and 21%
Induces euphoria and relaxation
May help people struggling with chronic pain
Unique sweet and spicy flavor

Cons:

Lower CBD content

Benefits and Effects

We start with arguably the most popular hybrid strain, the famed and well-known Northern Lights. Northern Lights was created during the ’70s homegrown revolution.

Today, this famous cannabis strain is one of the most sought-after cannabis strains worldwide, and it is a staple in the cannabis industry.

Its effects are primarily euphoric and relaxing, making it an excellent choice for stress and anxiety management.

It also offers potential benefits for those struggling with insomnia and chronic pain. Despite its potency (16% to 21%), the Northern Lights strain maintains a formal presence in the cannabis industry.

What’s the Northern Lights Great for

As mentioned, known for offering euphoric and relaxing effects, the Northern Lights strain may benefit people dealing with physical discomfort.

At the same time, some cannabis consumers who struggle with maintaining a healthy sleep cycle also love it.

THC Potency

Compared to different strains in the hybrid family, Northern Lights is not among the most potent cannabis plants.

However, it still produces a buzzing body high with a THC concentration ranging from 16% to 21%, depending on the breeder.

Where Can You Buy Northern Lights

You can buy top-grade Northern Lights seeds at Seed Supreme, and the renowned company offers over 4,000 other Indica, Sativa, and hybrid strains, meaning there is a strain for everyone.

Shopping at the biggest seed bank in the USA also makes you eligible for a 10% discount on your first order, while you also benefit from a 100% Germination Guarantee.

Summary

Despite its moderate potency, the Northern Lights strain stands out for its ability to deliver a balanced, high, and satisfying experience.

This particular strain is characterized by its sweet, spicy aroma and the subtle hint of pine that lingers after consumption, adding to its overall appeal.

>>Check the best price for Northern Lights at Seed Supreme

2. Granddaddy Purple – Calming and Relaxing Effect

Pros:

Known for producing high yields
Induces relaxation and calmness
THC between15% and 19%
Causes both cerebral and physical effects

Cons:

May cause sedation in some consumers

Benefits and Effects

The Granddaddy Purple is yet another famed hybrid cannabis Indica dominant strain characterized by its delightful scent, a blend of sweet fruits like grapes and berries with a noticeable floral undertone.

This cannabis Indica strain’s compact size, ease of cultivation, and high productivity can be attributed to its Kush lineage.

Compared to other hybrid cannabis strains, this hybrid Indica strain is best known for inducing calmness and relaxation with minor sedation.

What’s Granddaddy Purple Great for

For recreational use, Granddaddy Purple is an excellent choice for those seeking relaxation and tranquility, especially after a long day or week.

Its effects are most beneficial during the evening, particularly for individuals struggling with sleep.

From a medicinal perspective, Granddaddy Purple is recognized for its potential benefits in treating insomnia due to its heavy physical effects. It may also be beneficial for individuals seeking relief from physical pain.

THC Potency

This THC content, coupled with a variety of dominant terpenes, contributes to a profoundly relaxing effect that not only calms the body but also aids in quieting a restless mind.

The overall experience is often described as blissful, which adds a positive aspect to the strain’s calming effect coming from its THC level, usually ranging from 15% to 19%.

Where Can You Buy Granddaddy Purple

ILGM is the best place to shop for Granddaddy Purple seeds, while the company’s assortment has hundreds of other hybrid cannabis strains if you want to experiment.

If you decide to shop here, you can save $10 on your first order.

Summary

Granddaddy Purple is a robust strain that stands out for its potency, potential therapeutic uses, and delightful sensory experience.

Despite its potency, it offers a balanced combination of cerebral and physical effects, making it a notable strain within the cannabis scene.

>>Check the best price for Granddaddy Purple at ILGM

3. Gorilla Glue #4 – Relaxation Mixing With Euphoria

Pros:

THC content up to 32%
Most experience relaxation with euphoria
Fast effect onset time
More balanced THC and CBD ratio

Cons:

Too potent for newbies to THC

Benefits and Effects

Despite its cannabis Sativa-dominant genetics, GG4 is known for delivering a full-body melt.

This could be attributed to the THC/CBD ratio, the terpene profile, or the effects of the cannabinoids present.

Alongside the intense body sensation, users can expect an uplifting, cerebral experience, depending on their tolerance level and previous experience with potent hybrid cannabis strains.

What’s GG4 Great for

GG4 is not typically recommended for morning use due to its potent effects. Instead, it is better suited for days off or as a way to unwind at the end of the day.

Recreational users often report a heavy-handed, immediate effect that leads to deep relaxation and euphoria.

4. Chocolope Fem – Body and Mind Stimulation

Pros:

OG Chocolate Thai and Cannalopehaze cross
Induces body and mind upliftment
THC ranging from 12% to 17%
May boost motivation and creativity

Cons:

Milder effects in more experienced THC consumers

Benefits and Effects

Among hybrid cannabis plants, Chocolope Fem is a prominent cannabis Sativa known for its unique genetic blend and unique qualities, resulting from a cross between Cannalopehaze and OG Chocolate Thai.

The strain is primarily Sativa-dominant, and just like other Sativa strains, it is known for inducing body and mind stimulation with mild euphoria and rather profound energizing effects, which those who struggle with chronic fatigue find very beneficial.

What’s Chocolope Fem Great for

Chocolope Fem’s most notable feature is its ability to provide a pleasant cannabis Sativa high that promotes relaxation, mental focus, and creativity without inducing excessive intoxication.

It also enhances sociability, making it a preferred choice for situations that require increased confidence.

This strain is also beneficial for those seeking a motivational boost, as it is often used in the morning to stimulate energy and creativity.

However, due to its cerebral effects, it is not recommended for night-time use as it may keep the brain active beyond desired sleeping hours, and this is also the case with other Sativa plants.

THC Potency

The combination of two unique parents has resulted in a weed strain with distinct characteristics and a moderate THC content, ranging from 12 to 17%.

The strain is primarily Sativa-dominant, with a 10% Indica to 90% Sativa ratio contributing to its stimulating and mentally engaging effects.

Where Can You Buy Chocolope Fem

DNA Genetics, with hundreds of hybrid cannabis strains, also offers the top-grade Chocolope Fem hybrid cannabis seeds.

Whether you are interested in Sativa or Indica strains, the company has got you covered, and shopping here also qualifies you for free shipping if your order exceeds $100.

Summary

One of the best hybrid strains is also known for its enticing aroma, reminiscent of coffee with underlying notes of earthiness and sweetness.

This scent intensifies in the flowers of the plant, adding to its overall appeal, while the pleasantness of energizing and uplifting effects are unrivaled.

>>Check the best price for Chocolope Fem at DNA Genetics

5. Grape Ape – Ideal for Experienced Users

Pros:

THC levels from 15% and 25%
Known for inducing intense effects
Induces calmness with euphoria
May help individuals with mood disorders

Cons:

Not ideal for newbies to THC

Benefits and Effects

Among the best Indica strains, we have the famed Grape Ape, and this Indica dominant hybrid is a distinguished variety known for its unique grape-like aroma and strong effects.

This strain is a remarkable fusion of Mendocino Purps, Skunk, and Afghani, cultivated by Apothecary Genetics and Barney’s Farm.

Grape Ape is cherished within the cannabis community, appealing to seasoned users.

What’s Grape Ape Great for

Users of Grape Ape often report feelings of happiness, euphoria, and calmness. These effects make it a preferred choice for recreational users seeking to unwind and enjoy a relaxed state of mind.

The strain’s ability to induce a carefree and enjoyable experience is one of its most appealing features.

In the world of hybrid cannabis strains, the Grape Ape Indica strain has gained traction for its potential health benefits.

Its soothing effects are believed to be beneficial in managing mood-related disorders, providing relief and comfort.

Moreover, the strain’s calming properties are reported to be effective in treating insomnia and other sleep disorders, potentially aiding users in achieving a peaceful and restful sleep.

THC Potency

The potency of Grape Ape is noteworthy, with THC levels typically ranging between 15% and 25%.

This makes it particularly suited to experienced users who appreciate its robust effects.

The strain is acclaimed for its ability to induce a state of carefree relaxation, which can be beneficial in managing mood-related disorders.

Where Can You Buy Grape Ape

We recommend you shop for Grape Ape at Seedsman, and the company has hundreds of unique hybrids you also want to check out.

The company’s overall rating is 4.43/5 based on over 4,000 verified reviews, and if you use the WELOVESEEDS10 promo code, you qualify for a 10% discount.

Summary

Grape Ape is a potent cannabis strain with unique characteristics, cherished for its unique aroma, profound effects, and potential health benefits.

Its popularity in both recreational and medical cannabis circles is just growing as more and more people are getting to know Grape Ape.

>>Check the best price for Grape Ape at Seedsman

6. Green Gelato – Stress-Relieving Effects

Pros:

Beneficial to people struggling with stress
It may alleviate muscle tension
Users experience cerebral upliftment
THC levels between 18% and 22%

Cons:

Not the easiest strain to grow

Benefits and Effects

Grape Ape, a distinguished strain hailing from the West Coast, is known for its intense potency and unique flavor profile.

7. Runtz Muffin – Very High THC Content

Pros:

High THC level around 29%
Causes pleasant and intense effects
Unique flavor mixing sweetness with fruitiness
Easy to take care of

Cons:

Does not do well in colder climates

Benefits and Effects

The Runtz Muffin strain of cannabis is a unique blend of three distinct phenotypes, resulting in a product that is 70% Indica and 30% Sativa.

This combination offers a rich, complex profile and a high THC content of 29%, making it a potent choice for cannabis consumers.

The genetic makeup of Runtz Muffin is the result of crossbreeding the Zkittlez and Gelato #33 strains with an infusion of Barney’s Farm’s Orange Punch, and compared to other popular strains, this is one option that those with a higher THC tolerance will find particularly delightful.

What’s Runtz Muffin Great for

The effects of the Runtz Muffin strain are described as both potent and soothing. Users report a rapid onset of euphoria, providing a respite from daily stressors and anxieties.

When consumed in moderation, this strain can offer tension relief throughout the day, making it a potentially beneficial choice for those seeking to alleviate stress and tension.

With its profound relaxation and uplifting effects, Runtz Muffin may be beneficial to people struggling with depression, while many consumers report it also helps with alleviating muscle tension.

THC Potency

If you are interested in strains of high potency, you will easily fall in love with Runtz Muffin. This is one of the most potent hybrids with a THC level of up to 29%, while some breeders have even more potent options.

The potency of the strain depends on the breeder, while the intensity of the effects you experience depends on your body chemistry and your previous experience.

Where Can You Buy Runtz Muffin

For top-grade Runtz Muffin seeds, you want to visit Herbies. The company is known for offering Germination Assurance while speedy delivery is guaranteed to US customers.

In addition, you get a free seed of your choice for each order you make that exceeds $21.

Summary

In conclusion, one of the most popular strains, Runtz Muffin, offers a potent, complex profile with significant potential benefits for stress and tension relief.

Its high THC content, unique flavor profile, and chemical compounds make it a distinctive choice within the cannabis market, especially if you have experience with potent strains of this kind.

>>Check the best price for Runtz Muffin at Herbies

8. Wedding Cake – Blend of Aromatic Compounds

Pros:

THC level around 27%
Induces profound cerebral stimulation
Consumers experience pleasant relaxation
Cherry Pie and Girl Scout Cookies cross

Cons:

Too potent for beginners

Benefits and Effects

The Wedding Cake strain, predominantly indica, is a highly sought-after variety renowned for its pleasant effects and interesting flavor profile.

This strain, scientifically known to have a THC content as high as 27% and an average CBD level of 0.1%, is a hybrid of Cherry Pie and Girl Scout Cookies.

The Wedding Cake strain is known to induce a cerebral stimulation that users often describe as “mildly psychedelic.”

It heightens awareness of one’s surroundings, leading to a state of hyper-awareness. After the initial cerebral high, users typically experience a deep relaxation phase, often referred to as “couchlock.”

The strain is known to maintain a heady sensation throughout its effects, contributing to a heightened sense of mindfulness and awareness.

What’s Wedding Cake Great for

Although not medically substantiated, some users report a reduction in anxiety owing to the uplifting effects of the Wedding Cake strain.

In addition to potentially being beneficial to people struggling with anxiety, Wedding Cake may also offer some relief to those struggling with depression; with its Indica lineage makes it a great choice when you need something to help you sleep at night.

THC Potency

The THC content of the Wedding Cake strain can range from 19% to 27%, depending on how it is cultivated.

It is important to note that the strain’s potency is usually on the higher side, making it less suitable for beginners. With minimal CBD levels, the THC in this strain has a more pronounced effect on the consumer.

Where Can You Buy Wedding Cake

MSNL Seeds is the last seed bank we wanted to feature here, and besides Wedding Cake, the renowned company also sells Pineapple Express, Blue Dream, Jack Herer, OG Kush, and other famed hybrids.

At MSNL Seeds, you can expect express shipping regardless of your location in the USA, while the company offers 10% discounts to customers who pay using a standard bank transfer.

Summary

The Wedding Cake strain is ideal for those looking for an uplifting strain with a unique flavor profile, but it may not be suitable for newbies.

Overconsumption may also lead to negative effects, so caution is advised, as with other hybrids discussed here.

>>Check the best price for Wedding Cake at MSNL Seeds

What Are Hybrid Weed Strains?

Cannabis hybrid strains are produced by crossing two distinct parent strains, Indica and Sativa.

In order to produce a strain with a well-rounded set of effects, hybrid strains aim to inherit the good qualities of both parents.

The process of creating hybrid strains is complex and demands a high level of horticultural and genetic knowledge.

Breeders choose parent strains with great care, keeping in mind particular qualities they wish to include in the hybrid. Those looking for more balanced effects usually cross Indica and Sativa.

Breeders generally look for the strain’s potency, flavor profile, growth style, and often potential therapeutic properties.

What Different Hybrid Strains Are There?

A hybrid cannabis plant, a crossbreed between Indica and Sativa strains, comes in three primary categories: Sativa-dominant, Indica-dominant, and balanced or 50-50 hybrid strains, and each category is briefly discussed below.

Sativa-Dominant Hybrid Strains

Sativa has a stronger genetic influence on hybrids that are Sativa-dominant. These strains are well-known for boosting energy, elevating mood, and inspiring creativity.

They are frequently used during the day because they give consumers a cerebral high that can keep them focused and socially engaged.

However, depending on the precise genetic combination of Sativa and Indica, the effects can differ. Thus, it is essential to learn about each strain’s special characteristics.

Indica-Dominant Hybrid Strains

On the opposite end of the spectrum are hybrid strains that are predominantly Indica. With a higher proportion of Indica genetics, these strains are recognized for their calming and soothing effects.

Hybrids with a high Indica content are usually used in the evening or right before bed to help consumers relax and attain a trance-like state.

Additionally, they may have benefits for reducing pain and anxiety, though again, specific effects may vary from strain to strain.

50-50 Hybrid Strains

Lastly, there are balanced or 50-50 popular hybrid strains, which hold an equal balance of Sativa and Indica genetics.

These strains aim to provide the best of both worlds, offering a blend of the uplifting and energizing effects of Sativa strains with the calming and soothing effects of Indica strains.

The result is a well-rounded experience that can be enjoyed at any time of the day.

>>Check the best price for Northern Lights at Seed Supreme

Potential Benefits of Using Hybrid Strains

First off, the adaptability of hybrid strains is what makes them so versatile.

By fusing the energizing cerebral stimulation of sativa strains with the calming physical benefits of Indica strains, they have the potential to provide the best of both worlds.

This special blend has the potential to produce a well-rounded, balanced experience that meets a variety of demands and tastes.

Second, hybrid strains can be modified to produce desired effects. Cultivators can adjust the ratios of Sativa and Indica through deliberate breeding to produce a strain with the required properties.

This makes it possible to customize a highly tailored cannabis experience to meet specific needs, such as pain relief, relaxation, mental clarity, or a mix of these.

Thirdly, hybrid strains provide better therapeutic results. According to research, popular hybrid strains’ diverse terpene and cannabinoid profiles may provide a cooperative effect known as the “entourage effect” [1].

This indicates that when the constituent parts are ingested in combination, their respective therapeutic effects are enhanced, which may result in more potent alleviation from symptoms including pain, anxiety, and insomnia.

Hybrid Strains Potential Risks

Experienced users might find this appealing, but new users might be overwhelmed by the strong effects, which could cause anxiety, paranoia, and other adverse psychological reactions associated with different strains.

Prolonged consumption of cannabis, including specific strains of high potency, may lead to respiratory problems, memory loss, and cognitive decline, but the most common side effects remain dry mouth and dry eyes.

>>Check the best price for Northern Lights at Seed Supreme

What Are Some Tips for Growing Hybrid Cannabis Strains?

It is essential to understand your hybrid strain’s genetic makeup to maximize development production.

Since hybrid marijuana seeds frequently take on the development traits of their parent strains, it is critical to provide an environment that meets their particular requirements. This involves maintaining the ideal ratios of nutrients, light, temperature, and humidity.
Pay special attention to your plants and look for any indications of illness or stress. It is possible for hybrids to acquire the weaknesses of their parent strains, which leaves them open to illness or pest infestation.
Pruning and training methods are frequently beneficial to hybrids.Pruning is the process of cutting off extra leaves and stems to focus more energy on developing buds. High-stress training (HST) and low-stress training (LST) are two training methods that can maximize light exposure and promote faster growth.

To get the most flavor and potency out of your hybrid strain, you must know when to harvest it. Pay attention to any variations in the trichomes’ color—the microscopic resin glands on the buds.
Proper curing is necessary to maintain the quality and improve the flavor of your buds after harvest.

How Do I Choose the Right Hybrid Cannabis Strain for Me?

What do you want to get out of using cannabis? Are you hoping for more energy and increased creativity, or are you just looking for calm and stress relief?

Maybe you want a medium-toned effect that combines elements of both. Finding the right strain can be greatly aided by determining the effects you hope to experience.

A hybrid strain with a lower THC level can be a nice place to start if you are new to cannabis products.

Higher THC strains are more powerful and can be too much for novices to handle. However, if you are a seasoned user, you could like a hybrid strain that has

User experiences and online reviews might offer insightful information about the effects of different hybrid strains.

Although each person’s experience is unique, these reviews can help you get a basic sense of what to anticipate. Look for reviews from people who share your preferences and aspirations.

You may also want to experiment with different combinations but still start with strains with low THC to ensure the safest THC experience.

>>Check the best price for Northern Lights at Seed Supreme

How We Chose the Best Hybrid Strains of Weed

Looking for the best hybrids, we start by examining the following factors.

Looking into the Pros and Cons of Each Strain

This enables us to understand the possible advantages and disadvantages of every hybrid strain and how they can satisfy various requirements and needs.

Examining Customer Feedback

We then go on to customer feedback. We think that the best hybrid strains can be found by consulting the experiences of actual users.

We examine evaluations and testimonies, searching for cannabis products most consumers are satisfied with.

Examining Strains’ Specifics

We pay close attention to the strain’s overall potency, consistency of effects, and ability to provide a well-balanced experience that brings together the greatest qualities of Sativa and Indica.

Looking Into Third-Party Lab-Testing

Lastly, we check for thorough testing. We examine each strain’s terpene and cannabinoid profiles by looking into third-party lab tests performed by acclaimed testing labs.

The efficacy of the finished cannabis product can be greatly impacted by the quality of the plant’s cultivation and processing. Thus, we also assess this.

FAQs

For more information on the best hybrids on the market, we hope you examine our FAQs section.

How Does a Sativa-Dominant Hybrid Strain Make You Feel?

Typically, a hybrid strain with a Sativa dominance stimulates sensations of elation, creativity, and vitality.

It is frequently linked to a cerebral high that sharpens focus and stimulates intellect. However, depending on the particular strain, the tolerance level, and the body chemistry of each user, the effects may differ.

Are Hybrid Weed Strains Better?

Combining the best of Sativa and Indica seed varieties, hybrids are often categorized as better, and they are especially preferred by those looking for more balanced effects.

What Is the Best Weed Strain of All Time?

The best weed strain of all time, according to many regular consumers, is Northern Lights, which is cherished for its unique flavor profile and pleasant effects.

What Is the Strongest Hybrid Cart?

Some of the strongest on the market include those derived from potent strains like Wedding Cake and Grape Ape.

What Is the Strongest Sativa Hybrid?

The strongest Sativa hybrid is Gorilla Glue #4, while Jack Herer, Sour Diesel, and Green Crack are also quite potent.

How Does an Indica-Dominant Hybrid Strain Make You Feel?

An Indica hybrid strain is perfect for use in the evenings since it is frequently linked to sedation and relaxation.

Users frequently describe sensations of calmness, bodily relaxation, and occasionally sleepiness.

Best Hybrid Weed Strains – Summary

The world of hybrids is as diverse as it is delightful, offering a unique blend of characteristics to satisfy the needs of most cannabis users.

From the potency of THC and CBD ratios to the aromatic allure of terpene profiles, the choice is limitless, but we still recommend you check out Northern Lights at Seed Supreme the next time you get ready for a THC journey.

We also hope you check out other hybrids featured here, and whichever choice you make, you truly believe you will have a delightful THC adventure; just please remain responsible.

References:

Ferber SG, Namdar D, Hen-Shoval D, Eger G, Koltai H, Shoval G, Shbiro L, Weller A. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Curr Neuropharmacol. 2020;18(2):87-96. doi: 10.2174/1570159X17666190903103923. PMID: 31481004; PMCID: PMC7324885.

Author Bio:

Corey B. Harrison: With a green thumb and a passion for the delicate art of marijuana cultivation, Corey has spent the past five years immersed in the world of cannabis growth and harvesting. Combining expertise in horticulture with a keen understanding of the cannabis plant’s unique characteristics, Corey has cultivated a deep knowledge of optimal growing conditions, strains, and harvesting techniques.